Aid on Spreadsheets

New natural product based entries to treatment of bacterial respiratory tract infections

Expanding the library of broad-spectrum antibiotics is a central component of combating bacterial respiratory tract infections. By extension, this pursuit is also directed at poverty reduction in the developing world as it is intrinsically linked to infectious diseases. To this end, the proposed project aims at advancing natural products with known activity against multi-drug resistant bacteria towards clinical relevance. We will develop efficient chemical syntheses (total and semi-synthetic routes) to access compounds that are not available through other means for biological and mechanistic investigation. The mechanistic work will be used to guide the development of improved and/or simplified structural analogs that can be used at a lower cost. Understanding how to rationally design complex phenylalanine mimetics and oleane triterpenoid structures in this context provides entries to rational development of new generations of small molecule antibiotics working through the same mechanism. The work is enabled by an interdisciplinary collaboration between synthetic chemists in Sweden and Uganda, natural product chemists in Mexico, and microbiologists in South Africa.

Project ID

SE-0-SE-29-2016-05685_2-285-12182

Activity status

2 - Implementation

Aid type

D02 - Other technical assistance

% to Uganda

100.00

Organisations

Funding

Sweden

Extending

The Swedish Research Council

Implementing

Lunds universitet

CRS code	%
Medical research (12182)	100.0